Synthesis of functionalized γ-lactams via copper-catalyzed intramolecular C-vinylation of activated methylene compounds

摘要

With the catalysis of CuI/3,4,7,8-tetramethyl-1,10-phenanthroline, a number of N-(2-iodoallyl)-2-(ethoxycarbonyl) alkanamides underwent efficient intramolecular C-vinylation in THF at 50 °C leading to the synthesis of functionalized γ-lactams in 61-99 yields.

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