Iron-Catalyzed Nitrene Insertion Reaction for Facile Construction of Amide Compounds

摘要

A facile method for the construction of amide compounds from aldehydes by an iron-catalyzed nitrene insertion reaction has been developed. Both aryl and aliphatic aldehydes can directly afford the corresponding amides with an iron(II)-terpyridine (tpy) complex formed in situ as catalyst, and PhI=NTs as nitrogen source under mild reaction conditions. An ESI-MS study revealed the formation of [Fe(tpy)(2)(NTs)](2+) as a reaction intermediate.

关键词